Phenotypes Associated with This Genotype

Genotype
MGI:3582674

• Allelic Composition: Apc^Min/Apc⁺; Blm^tm1Grdn/Blm⁺
• Genetic Background: involves: 129P2/OlaHsd * 129S/SvEv * Black Swiss * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

neoplasm

increased gastrointestinal tumor incidence ( J:79058 )

• developed twice as many gastrointestinal adenomas as single heterozygous Apc mutant mice (31.4 tumors/mouse vs. 14.2 tumors/mouse in wildtype), however tumors were similar in size

increased intestinal adenoma incidence ( J:79058 )

• developed low- and high-grade adenomas in the small intestine, whereas only low-grade adenomas were seen in heterozygous Apc mutant mice

increased colon adenoma incidence ( J:79058 )

• all colonic adenomas displayed high-grade dysplasia

digestive/alimentary system

increased gastrointestinal tumor incidence ( J:79058 )

• developed twice as many gastrointestinal adenomas as single heterozygous Apc mutant mice (31.4 tumors/mouse vs. 14.2 tumors/mouse in wildtype), however tumors were similar in size

increased intestinal adenoma incidence ( J:79058 )

• developed low- and high-grade adenomas in the small intestine, whereas only low-grade adenomas were seen in heterozygous Apc mutant mice

increased colon adenoma incidence ( J:79058 )

• all colonic adenomas displayed high-grade dysplasia

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Bloom syndrome		DOID:2717	OMIM:210900	J:79058