Phenotypes Associated with This Genotype

Genotype
MGI:3582680

• Allelic Composition: Mafa^tm1Staka/Mafa^tm1Staka
• Genetic Background: involves: ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

growth/size/body

postnatal growth retardation ( J:99126 )

• females displayed significant growth retardation postnatally from 8 weeks onward

homeostasis/metabolism

decreased insulin secretion ( J:99126 )

• almost no acute insulin secretion in response to elevated blood glucose levels and pancreatic islets did not secrete insulin in response to glucose, arginine, or KCl stimulation in vitro

increased circulating glucose level ( J:99126 )

• significantly higher fasting blood glucose levels in females at 4 weeks of age, and both males and females had high blood glucose levels at 8 weeks of age

decreased circulating insulin level ( J:99126 )

• significantly lower plasma insulin levels after glucose injection (0.51 ng/ml vs 1.51 ng/ml in wild-type) or arginine administration

impaired glucose tolerance ( J:99126 )

• significantly higher blood glucose levels than wild-type in a glucose tolerance test

increased urine glucose level ( J:99126 )

• 5/19 adult males became urinary glucose positive by 20 weeks of age

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:99126 )

• significant difference in the structure of islets and the ratio of beta to alpha cells at 12 weeks of age but not at P1

decreased insulin secretion ( J:99126 )

• almost no acute insulin secretion in response to elevated blood glucose levels and pancreatic islets did not secrete insulin in response to glucose, arginine, or KCl stimulation in vitro

renal/urinary system

increased urine glucose level ( J:99126 )

• 5/19 adult males became urinary glucose positive by 20 weeks of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young		DOID:0050524	OMIM:606391	J:99126
type 2 diabetes mellitus		DOID:9352	OMIM:125853 OMIM:601283 OMIM:601407 OMIM:603694 OMIM:608036	J:99126