Phenotypes Associated with This Genotype

Genotype
MGI:3582934

• Allelic Composition: Bicc1^jcpk/Bicc1^jcpk-bpk
• Genetic Background: involves: 101 * BALB/c * C3H * C57BL/6J * T STOCK

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

renal/urinary system

kidney cyst ( J:36348 )

• small opalescent cysts seen at 11 to 17 days of age

• cysts are radially arrayed, a pattern typical of cysts in the collecting ducts and cystic dilation of Bowman's space involving about 17% of glomeruli, similar to Bicc1^jcpk-bpk homozygotes

enlarged kidney ( J:36348 )

liver/biliary system

abnormal bile duct morphology ( J:36348 )

• tortuous ducts are generally lined with hyperplastic epithelium

dilated gallbladder ( J:36348 )

• gall bladder dilation is common

abnormal portal lobule morphology ( J:36348 )

• expanded portal tracts with multiple irregularly shaped and variably dilated bile ducts

abnormal portal triad morphology ( J:36348 )

• the portal triad is expanded by hematopoietic cells and immature stromal cells

pale liver ( J:36348 )

• liver parenchyma is pale

growth/size/body

kidney cyst ( J:36348 )

• small opalescent cysts seen at 11 to 17 days of age

• cysts are radially arrayed, a pattern typical of cysts in the collecting ducts and cystic dilation of Bowman's space involving about 17% of glomeruli, similar to Bicc1^jcpk-bpk homozygotes

distended abdomen ( J:36348 )

• visible by 7 to 10 days of age

enlarged kidney ( J:36348 )

endocrine/exocrine glands

abnormal bile duct morphology ( J:36348 )

• tortuous ducts are generally lined with hyperplastic epithelium

dilated gallbladder ( J:36348 )

• gall bladder dilation is common

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
autosomal recessive polycystic kidney disease		DOID:0110861		J:36348