Phenotypes Associated with This Genotype

Genotype
MGI:3582985

cx4

• Allelic Composition: Krt18^tm1Tmm/Krt18^tm1Tmm; Krt19^tm2Mmt/Krt19^tm2Mmt
• Genetic Background: involves: 129/Sv * 129P2/OlaHsd * 129S2/SvPas * C57BL/6 * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:65090 )

• no homozygotes at birth

• embryonic death between E9.5 and E10.5

embryo

decreased embryo size ( J:65090 )

• embryos smaller than controls but otherwise normal at E9.5

abnormal extraembryonic tissue morphology ( J:65090 )

• bleeding in extraembryonic tissues between the maternal deciduas and yolk sac at E10.5

abnormal trophoblast giant cell morphology ( J:65090 )

• trophoblast giant cells were cytolytic

small placenta ( J:65090 )

• placentas smaller in diameter but otherwise normally developed

growth/size/body

decreased embryo size ( J:65090 )

• embryos smaller than controls but otherwise normal at E9.5