Phenotypes Associated with This Genotype

Genotype
MGI:3583142

• Allelic Composition: Itgb2^tm1Bay/Itgb2^tm1Bay
• Genetic Background: involves: 129S7/SvEvBrd * C57BL/6J * PL/J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

dermatitis ( J:84126 )

• Background Sensitivity: 23.5% of the F2 progeny from a PL/J x C57BL/6J intercross develop psoriasiform dermatitis, which is not observed on a 129S7/SvEvBrd or a mixed 129S7/SvEvBrd and C57BL/6J background

integument

integument phenotype ( J:32126 , J:84126 )

N • Background Sensitivity: F1 mice from intercrosses of homozygotes on PL/J and C57BL/6J backgrounds did not develop progressive dermatitis, however when F1 mice were backcrossed to homozygotes on the PL/J background, 50% developed dermatitis (J:32126)

N (J:84126)

dermatitis ( J:84126 )

• Background Sensitivity: 23.5% of the F2 progeny from a PL/J x C57BL/6J intercross develop psoriasiform dermatitis, which is not observed on a 129S7/SvEvBrd or a mixed 129S7/SvEvBrd and C57BL/6J background

alopecia ( J:84126 )

• approximately half of affected F2 mice develop severe disease with various degrees of alopecia

reddish skin ( J:84126 )

• Background Sensitivity: approximately half of affected F2 mice develop only mild disease with erythema and/or dry skin, which is not observed on a 129S7/SvEvBrd or a mixed 129S7/SvEvBrd and C57BL/6J background

psoriasis ( J:84126 )

• 23.5% of the F2 progeny from a PL/J x C57BL/6J intercross develop chronic inflammatory skin disease with highly variable severity

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
psoriasis		DOID:8893	OMIM:PS177900	J:32126 , J:84126