Phenotypes Associated with This Genotype

Genotype
MGI:3583335

• Allelic Composition: Ret^tm2.1Cos/Ret⁺
• Genetic Background: involves: 129S1/Sv * C57BL/6J * FVB/N

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

endocrine/exocrine glands

adrenergic chromaffin cell hyperplasia ( J:60659 )

• 16-17% display nodular chromaffin cell hyperplasia, rarely progressing to pheochromocytoma

thyroid gland hyperplasia ( J:60659 )

• 31% of young and 41% of older mutants display diffuse C-cell hyperplasia and 14% have more advanced nodular C-cell hyperplasia

nervous system

adrenergic chromaffin cell hyperplasia ( J:60659 )

• 16-17% display nodular chromaffin cell hyperplasia, rarely progressing to pheochromocytoma

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	familial medullary thyroid carcinoma	DOID:0050547	OMIM:155240	J:60659
multiple endocrine neoplasia type 2B		DOID:10016	OMIM:162300	J:60659