Phenotypes Associated with This Genotype

Genotype
MGI:3583686

• Allelic Composition: Gck^tm1Tka/Gck⁺
• Genetic Background: involves: 129X1/SvJ * ICR

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:30334 )

• heterozygous islets show normal insulin secretion in response to 0.1 mM or 3 mM glucose but not in response to 10 mM glucose; a less pronounced defect is noted in response to 20 mM glucose

• in contrast, heterozygous islets display a relatively normal insulin secretion in response to glibenclamide or arginine

hyperglycemia ( J:30334 )

• at 10 weeks, heterozygotes display significantly higher blood glucose levels both before and after a glucose load relative to wild-type mice

• however, heterozygotes have normal blood glucose levels at birth

impaired glucose tolerance ( J:30334 )

• heterozygotes exhibit mild glucose intolerance due to an impaired insulin response to glucose

increased urine glucose level ( J:30334 )

• ~50% of heterozygotes display mild glycosuria within a day, suggesting the development of early-onset mild diabetes mellitus

endocrine/exocrine glands

decreased insulin secretion ( J:30334 )

• heterozygous islets show normal insulin secretion in response to 0.1 mM or 3 mM glucose but not in response to 10 mM glucose; a less pronounced defect is noted in response to 20 mM glucose

• in contrast, heterozygous islets display a relatively normal insulin secretion in response to glibenclamide or arginine

renal/urinary system

increased urine glucose level ( J:30334 )

• ~50% of heterozygotes display mild glycosuria within a day, suggesting the development of early-onset mild diabetes mellitus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:30334