Phenotypes Associated with This Genotype

Genotype
MGI:3583695

• Allelic Composition: Itga9^tm1Des/Itga9^tm1Des
• Genetic Background: involves: 129S4/SvJae * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:63038 )

• appear normal for 4-6 days after birth

• mice die within 2 days of the onset of respiratory distress which occurs around day 6-12

• survival can be prolonged by draining fluid in thorax but only to about 21 days of age

growth/size/body

postnatal growth retardation ( J:63038 )

• smaller than littermate controls by day 6-8

respiratory system

chylothorax ( J:63038 )

• high concentrations of both triglycerides and cholesterol

• 90% of cells in fluid collected in the thoracic cavity were lymphocytes

respiratory distress ( J:63038 )

• all mice show signs of respiratory distress between 6 and 12 days of age

immune system

abnormal lymph circulation ( J:63038 )

• edema and lymphocytes sometimes seen in tissue surrounding thoracic duct

cardiovascular system

abnormal lymph circulation ( J:63038 )

• edema and lymphocytes sometimes seen in tissue surrounding thoracic duct

homeostasis/metabolism

chylothorax ( J:63038 )

• high concentrations of both triglycerides and cholesterol

• 90% of cells in fluid collected in the thoracic cavity were lymphocytes

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congenital chylothorax		DOID:0060646	OMIM:603523	J:63038