Phenotypes for Gast Ins2 MGI:3583903 MGI Mouse

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Phenotypes Associated with This Genotype

Allelic Composition	Gast^tm1(INS)Ez/Gast⁺ Ins2^Akita/Ins2⁺
Genetic Background	involves: 129S4/SvJae * C57BL/6NSlc

Find Mice

Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Gast^tm1(INS)Ez mutation (1 available); any Gast mutation (18 available)
Ins2^Akita mutation (14 available); any Ins2 mutation (93 available)

♀	phenotype observed in females
♂	phenotype observed in males
N	normal phenotype

mortality/aging

mortality/aging ( J:99270 )

N	• double heterozygotes live over 13 months compared to Ins2^Akita single heterozygotes which have a median survival time of 10.3 months

homeostasis/metabolism

abnormal circulating glucose level ( J:99270 )

• a significant decrease in fasting hyperglycemia is seen in double heterozygotes compared to Ins2^Akita single heterozygotes

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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