Phenotypes Associated with This Genotype

Genotype
MGI:3584111

cn13

• Allelic Composition: Smo^tm1Amc/Smo^tm2Amc; Tg(Col2a1-cre)10Amc/0
• Genetic Background: involves: 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cellular

decreased chondrocyte proliferation ( J:73071 )

• decrease in chondrocyte proliferation at E14.5, however chondrocyte differentiation proceeds normally

mortality/aging

postnatal lethality, complete penetrance ( J:73071 )

• small number of mutant pups survive for up to 9 days postpartum

skeleton

decreased chondrocyte proliferation ( J:73071 )

• decrease in chondrocyte proliferation at E14.5, however chondrocyte differentiation proceeds normally

decreased length of long bones ( J:73071 )

• shorter long bones with no growth of long bones after birth and defects more severe than in mutants carrying Tg(Col2a1-cre)15Amc or Tg(Col2a1-cre)3Amc

short humerus ( J:73071 )

short ulna ( J:73071 )

• short ulna

short fibula ( J:73071 )

short tibia ( J:73071 )

• almost no growth of tibia after birth

short scapula ( J:73071 )

• length of scapula is shorter

abnormal skeleton development ( J:73071 )

• skeletal growth retardation

limbs/digits/tail

abnormal digit morphology ( J:73071 )

• failure of digit segmentation and ossification

short humerus ( J:73071 )

short ulna ( J:73071 )

• short ulna

short fibula ( J:73071 )

short tibia ( J:73071 )

• almost no growth of tibia after birth

short limbs ( J:73071 )

• 40-50% reduction in the length of the stylopod and the zeugopod at birth