Phenotypes Associated with This Genotype

Genotype
MGI:3584136

• Allelic Composition: Tg(TcraTcrbNY8.3)1Pesa/?
• Genetic Background: involves: C57BL/6 * NOD * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

pancreas inflammation ( J:44202 )

• insulitis at 3 weeks less than in controls

• insulitis at 6 weeks of age significantly greater than in controls

homeostasis/metabolism

increased circulating glucose level ( J:44202 )

• diabetes develops in 26% (males) to 33% (females) of mice

• diabetes slow to develop and moderate

endocrine/exocrine glands

pancreas inflammation ( J:44202 )

• insulitis at 3 weeks less than in controls

• insulitis at 6 weeks of age significantly greater than in controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
type 1 diabetes mellitus		DOID:9744	OMIM:222100	J:44202