Phenotypes Associated with This Genotype

Genotype
MGI:3584436

• Allelic Composition: Ins1^tm1Jja/Ins1^tm1Jja; Ins2^tm1Jja/Ins2^tm1Jja
• Genetic Background: involves: 129S2/SvPas

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

Growth retardation of Ins1^tm1Jja/Ins1^tm1Jja Ins2^tm1Jja/Ins2^tm1Jja mice

mortality/aging

postnatal lethality, complete penetrance ( J:40377 )

• death in 48 hours after birth on average

endocrine/exocrine glands

increased pancreatic beta cell number ( J:77595 )

• significant hyperplasia

enlarged pancreatic islets ( J:40377 )

• about 1.5X larger than in littermate controls

homeostasis/metabolism

increased circulating triglyceride level ( J:40377 )

• milky plasma

abnormal glucose homeostasis ( J:40377 , J:77595 )

• severely diabetic (J:77595)

increased urine glucose level ( J:40377 )

• glycosuria detectable after pups suckle

acidosis ( J:40377 )

• ketoacidosis

growth/size/body

embryonic growth retardation ( J:40377 )

decreased body size ( J:40377 )

• mean body weight within a few hours of birth 22% less than littermate controls

enlarged liver ( J:40377 )

liver/biliary system

enlarged liver ( J:40377 )

hepatic steatosis ( J:40377 )

renal/urinary system

increased urine glucose level ( J:40377 )

• glycosuria detectable after pups suckle

embryo

embryonic growth retardation ( J:40377 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young		DOID:0050524	OMIM:606391	J:40377 , J:77595