Phenotypes Associated with This Genotype

Genotype
MGI:3584454

• Allelic Composition: Emx1^tm1(cre)Ito/?; Gt(ROSA)26Sor^{tm1(HD*103Q)Xwy}/?
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

nervous system phenotype ( J:99759 )

N • mice have comparable locomotor activity to wild-type controls

N • gliosis levels are comparable to wild-type

N • dendrites with abnormal or wavy morphology occur with similar frequency in mutants and wild-type controls

N • very few neurons showing early stages of degeneration are observed

N • electrophysiology such as sIPSCs from cortical neurons are normal relative to controls

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Huntington's disease	DOID:12858	OMIM:143100	J:99759