Phenotypes Associated with This Genotype

Genotype
MGI:3584464

• Allelic Composition: Trp53^tm1Tyj/Trp53^tm2.1Tyj
• Genetic Background: involves: 129S2/SvPas * 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:95316 )

• mean life span is 4.5 months

prenatal lethality, incomplete penetrance ( J:95316 )

• a slight decrease is seen in the number of females born

neoplasm

increased tumor incidence ( J:95316 )

• 57% have multiple tumors, significantly more than in Trp53^tm1Tyj homozygotes (32%)

increased T cell derived lymphoma incidence ( J:95316 )

• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53^tm1Tyj homozygotes (50% compared to 66%)

increased carcinoma incidence ( J:95316 )

• carcinomas are seen in 16% of mice, with most carcinomas showing signs of invasion, metastasis, or other features of advanced human carcinomas

• most carcinomas are derived from epithelial cells

increased hemangiosarcoma incidence ( J:95316 )

• the incidence of hemangiosarcomas is increased to 62% compared to 32% in Trp53^tm1Tyj homozygotes and these tumors are highly aggressive

endocrine/exocrine glands

increased T cell derived lymphoma incidence ( J:95316 )

• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53^tm1Tyj homozygotes (50% compared to 66%)

hematopoietic system

increased T cell derived lymphoma incidence ( J:95316 )

• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53^tm1Tyj homozygotes (50% compared to 66%)

immune system

increased T cell derived lymphoma incidence ( J:95316 )

• a slight decrease in hematological malignancies (primarily T cell lymphomas) is seen compared to Trp53^tm1Tyj homozygotes (50% compared to 66%)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Li-Fraumeni syndrome		DOID:3012	OMIM:PS151623	J:95316