Phenotypes Associated with This Genotype

Genotype
MGI:3584470

• Allelic Composition: Trp53^tm3.1Tyj/Trp53⁺
• Genetic Background: involves: 129S4/SvJae

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:95316 )

• mean life span is 15.8 months

neoplasm

increased metastatic potential ( J:95316 )

• compared to Trp53^tm1Tyj

increased tumor incidence ( J:95316 )

increased B cell derived lymphoma incidence ( J:95316 )

• 5 of 36 develop B cell lymphomas generally arising in the spleen or mesenteric lymph nodes

increased carcinoma incidence ( J:95316 )

• the incidence of carcinomas is increased compared to Trp53^tm1Tyj heterozygotes

• 5 of 36 develop squamous cell carcinomas and a single case each of transitional cell renal carcinoma and intestinal carcinoma are seen

increased hepatocellular carcinoma incidence ( J:95316 )

• 2 of 36 develop hepatocellular carcinomas

increased lung adenocarcinoma incidence ( J:95316 )

• 7 of 36 develop lung adenocarcinomas, several with malignant features commonly seen in human lung adenocarcinoma including nuclear atypia (5 of 7), desmoplasia (4 of 7), and metaplasias (2 of 7)

increased squamous cell carcinoma incidence ( J:95316 )

• 5 of 36 develop squamous cell carcinomas

cellular

decreased cellular sensitivity to gamma-irradiation ( J:95316 )

• resistance to gamma-irradiation induced apoptosis is increased compared to Trp53^tm1Tyj hterozygotes

increased cell proliferation ( J:95316 )

• a larger fraction of MEFs are in S phase compared to Trp53^tm1Tyj hterozygotes; however DNA damage-induced G1 arrest is intact

respiratory system

increased lung adenocarcinoma incidence ( J:95316 )

• 7 of 36 develop lung adenocarcinomas, several with malignant features commonly seen in human lung adenocarcinoma including nuclear atypia (5 of 7), desmoplasia (4 of 7), and metaplasias (2 of 7)

liver/biliary system

increased hepatocellular carcinoma incidence ( J:95316 )

• 2 of 36 develop hepatocellular carcinomas

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Li-Fraumeni syndrome		DOID:3012	OMIM:PS151623	J:95316