renal/urinary system
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors
|
mortality/aging
• mean life span is 15.4 months
|
neoplasm
• 19% have multiple tumors compared to 44% of Trp53tm3.1Tyj heterozygotes
|
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors
|
• 4 of 37 develop low grade carcinomas including 1 with a well differentiated lung carcinoma
|
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors
|
cellular
• in thymocytes exposed to gamma radiation
|
• in response to irradiation
|
• a larger fraction of MEFs are in S phase compared to wild-type mice
|
hematopoietic system
• hematopoietic stem and progenitor cells (HSPC) from irradiated mice transplanted into irradiated mice reconstitute the HSPC population exhibit a competitive advantage over HSPC from untreated mice compared with cells from similarly irradiated wild-type mice
• however, no competitive advantage is observed over similarly treated Cdkn2atm2.1Rdp cells in irradiation chimera experiments
|
• in response to irradiation
|
immune system
• in response to irradiation
|
homeostasis/metabolism
• 12 of 45 mice treated with 2-AAF develop urinary bladder tumors
|
endocrine/exocrine glands
• in response to irradiation
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
Li-Fraumeni syndrome | DOID:3012 |
OMIM:PS151623 |
J:95316 |