digestive/alimentary system
N |
• at 18.5 dpc, homozygotes exhibit no intestinal transformation of the stomach epithelium
|
• at 18.5 dpc, homozygotes display a smaller gastrointestinal tract relative to wild-type
|
• at 18.5 dpc, all homozygotes display an obvious malrotation of the gut, in the absence of reversions in gut situs
|
• at 18.5 dpc, homozygotes display a significant dilation of parts of the colon as well as a thin wall
|
• at 18.5 dpc, 50% of homozygotes display an aganglionic megacolon
|
• at 18.5 dpc, homozygotes show a significant dilation of the small intestine
• at 18.5 dpc, homozygotes show a 34% reduction in thickness of the circular smooth muscle layer along the small intestine
• at this stage, the size of mutant villi is markedly reduced concomitant with a 54% decrease in epithelial stem cell proliferation between and at the base of villi
|
• at 18.5 dpc, homozygotes show a 45% reduction in the number of cholecystokinin-producing cells of the duodenum
• at 18.5 dpc, no duodenal stenosis is observed
|
growth/size/body
• at 18.5 dpc, mutant embryos have an overall reduced size relative to wild-type embryos
|
nervous system
• at 18.5 dpc, enteric neurons are completely absent along parts of the small intestine and in dilated portions of the colon
|
endocrine/exocrine glands
• at 18.5 dpc, 43% of homozygotes exhibit an annular pancreas
|
muscle
• at 18.5 dpc, homozygotes show a 34% reduction in thickness of the circular smooth muscle layer along the small intestine
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
annular pancreas | DOID:0060850 |
OMIM:167750 |
J:62158 | |
Hirschsprung's disease | DOID:10487 |
OMIM:600156 OMIM:606874 OMIM:606875 OMIM:608462 OMIM:611644 |
J:62158 |