Phenotypes Associated with This Genotype

Genotype
MGI:3584512

• Allelic Composition: Tg(Amelx)42Msnd/Tg(Amelx)42Msnd
• Genetic Background: involves: C57BL/6J * CBA/J * DBA/2J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

craniofacial

abnormal enamel mineralization ( J:100004 )

• transmission electron microscopy of the enamel matrix of neonatal incisors reveals non-uniformity in the size of the self-assembled amelogenin nanospheres and disruption of the normally evenly-spaced, parallel arrangement of the hydroxyapatite crystallites

abnormal enamel rod pattern ( J:100004 )

• scanning electron micrographs of incisors of 6 week old mice reveal loss of the normal boundary definiton of the rods comprising the enamel and abnormal porosity of the structure formed by the rods

skeleton

abnormal enamel mineralization ( J:100004 )

• transmission electron microscopy of the enamel matrix of neonatal incisors reveals non-uniformity in the size of the self-assembled amelogenin nanospheres and disruption of the normally evenly-spaced, parallel arrangement of the hydroxyapatite crystallites

abnormal enamel rod pattern ( J:100004 )

• scanning electron micrographs of incisors of 6 week old mice reveal loss of the normal boundary definiton of the rods comprising the enamel and abnormal porosity of the structure formed by the rods

growth/size/body

abnormal enamel mineralization ( J:100004 )

• transmission electron microscopy of the enamel matrix of neonatal incisors reveals non-uniformity in the size of the self-assembled amelogenin nanospheres and disruption of the normally evenly-spaced, parallel arrangement of the hydroxyapatite crystallites

abnormal enamel rod pattern ( J:100004 )

• scanning electron micrographs of incisors of 6 week old mice reveal loss of the normal boundary definiton of the rods comprising the enamel and abnormal porosity of the structure formed by the rods

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	amelogenesis imperfecta type 1E	DOID:0110058	OMIM:301200	J:100004