Phenotypes Associated with This Genotype

Genotype
MGI:3586342

• Allelic Composition: Csf2^tm1Dran/Csf2^tm1Dran; Il3^tm1Glli/Il3^tm1Glli
• Genetic Background: B6.129S2-Csf2^tm1Dran Il3^tm1Glli

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

increased eosinophil cell number ( J:67404 )

• increase in circulating eosinophiles but not in bone marrow

abnormal leukocyte physiology ( J:83086 )

• defective phagocytosis of apoptotic cells

decreased susceptibility to type IV hypersensitivity reaction ( J:67404 )

• dramatically reduced response to secondary challenge in tests for contact hypersensitivity

• very reduced cellular infiltrates

• much reduced edema

• very little keratinocyte activation

increased anti-double stranded DNA antibody level ( J:83086 )

• increased level of anti double stranded DNA

glomerulonephritis ( J:83086 )

• appears after 8 months of age

• B and T cell aggregates in the renal pelvis and liver

lung inflammation ( J:67404 )

• extensive lymphoid hyperplasia around both airways and veins

respiratory system

lung inflammation ( J:67404 )

• extensive lymphoid hyperplasia around both airways and veins

abnormal surfactant secretion ( J:83086 )

• accumulation of surfactant in intra-alveolar spaces

renal/urinary system

glomerulonephritis ( J:83086 )

• appears after 8 months of age

• B and T cell aggregates in the renal pelvis and liver

hematopoietic system

increased eosinophil cell number ( J:67404 )

• increase in circulating eosinophiles but not in bone marrow

abnormal leukocyte physiology ( J:83086 )

• defective phagocytosis of apoptotic cells

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
systemic lupus erythematosus		DOID:9074	OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420	J:83086