Analysis Tools
mortality/aging
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• surviving mice became moribund with time
• most died or had to be euthanized before 14 months of age
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• about 40% of homozygotes died of pneumonia in the first few weeks of life
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immune system
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• mild eosinophilia in mice surviving beyond the first few weeks of life
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• serum levels increased but not significantly
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• significantly higher serum IgG1 levels
• non significant increases in serum IgG2b levels
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• acute and chronic inflammatory reactions found in many organs and tissues
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neoplasm
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• Lymphoproliferative disease in a high proportion of mice
• develops into B cell lymphomas
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• solid tumors are benign to metastasizing carcinomas
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 |
• particularly prevalent
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hematopoietic system
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• mild eosinophilia in mice surviving beyond the first few weeks of life
|
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• serum levels increased but not significantly
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• significantly higher serum IgG1 levels
• non significant increases in serum IgG2b levels
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endocrine/exocrine glands
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• particularly prevalent
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reproductive system
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• particularly prevalent
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| NOT | systemic lupus erythematosus | DOID:9074 |
OMIM:152700 OMIM:300809 OMIM:605480 OMIM:608437 OMIM:609903 OMIM:609939 OMIM:610065 OMIM:610066 OMIM:612254 OMIM:612378 OMIM:613145 OMIM:614420 |
J:83086 |
