Phenotypes Associated with This Genotype

Genotype
MGI:3586619

• Allelic Composition: Tg(Myh6-Tnf)2Brgi/?
• Genetic Background: involves: C57BL/6J * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:100006 )

• died by around 10 months of age

• a few days after the onset of clinical symptoms

cardiovascular system

dilated heart atrium ( J:100006 )

• biatrial

globular heart ( J:100006 )

abnormal heart ventricle morphology ( J:100006 )

• biventricle dilation

cardiac fibrosis ( J:84829 , J:100006 )

• intersitial fibrosis of atria and ventricles (J:84829)

• biventricular fibrosis (J:100006)

decreased heart ventricle muscle contractility ( J:100006 )

• depressed ventricle ejection fraction

myocarditis ( J:84829 , J:100006 )

• mononuclear inflammatory cells and fibroblasts (J:84829)

• diffuse interstitial cellularity (J:84829)

• transmural (J:100006)

behavior/neurological

poor grooming ( J:100006 )

abnormal motor capabilities/coordination/movement ( J:100006 )

hunched posture ( J:100006 )

decreased locomotor activity ( J:100006 )

respiratory system

abnormal respiration ( J:100006 )

• edematous and congested lungs

tachypnea ( J:100006 )

• increased respiration

immune system

myocarditis ( J:84829 , J:100006 )

• mononuclear inflammatory cells and fibroblasts (J:84829)

• diffuse interstitial cellularity (J:84829)

• transmural (J:100006)

homeostasis/metabolism

abnormal atrial thrombosis ( J:100006 )

muscle

decreased heart ventricle muscle contractility ( J:100006 )

• depressed ventricle ejection fraction

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
congestive heart failure		DOID:6000		J:100006