Phenotypes Associated with This Genotype

Genotype
MGI:3586704

• Allelic Composition: Fzd9^tm1Sjp/Fzd9^tm1Sjp
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

increased susceptibility to pharmacologically induced seizures ( J:99893 )

• at 10 months of age, latency of seizure onset is about half that of wild-type or heterozygous mice; however spontaneous seizures are not seen

abnormal forebrain development ( J:99893 )

• at E14.5 there is a slight but significant increase in M-phase precursor cells in the medial cortical wall and at E18.5 there is a significant increase in M-phase precursor cells in the dentate gyrus; however by P8 no difference is seen

• at E14.5 a more than 5-fold increased in the number of apoptotic cell clusters and the number of cells per cluster is detected in the dentate anlage and later in gestation, about a 3-fold increase in the number of apoptotic cells in the dentate and fimbria is detected by TUNEL staining

abnormal dentate gyrus morphology ( J:99893 )

• a 20% decrease in the number of dentate granule cells is seen at 12 weeks of age; however no change in the number of pyramidal cells is detected

• a dramatic increase in the mossy cell number and a substantial increase in neuronal density are seen in the hilus

behavior/neurological

increased susceptibility to pharmacologically induced seizures ( J:99893 )

• at 10 months of age, latency of seizure onset is about half that of wild-type or heterozygous mice; however spontaneous seizures are not seen

abnormal spatial learning ( J:99893 )

• visually mediated, spatial memory is impaired

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Williams-Beuren syndrome		DOID:1928	OMIM:194050	J:99893