Analysis Tools
mortality/aging
|
• reduced lifespan, with 67% mortality between 6 and 14 months of age
|
growth/size/body
weight loss
(
J:6337
)
|
• older mice exhibit sudden weight loss before death
|
|
• homozygotes accumulated excessive fat by 3 weeks of age
• by 6 months of age, mice weighed from 70-90 grams compared to 20-28 grams in controls
|
behavior/neurological
polyphagia
(
J:6337
)
endocrine/exocrine glands
|
• necrosis of the exocrine, but not the endocrine pancreas was noted in aging animals
|
|
• less than 2-fold increase in the number of alpha cells per islet
|
|
• beta cell hyperplasia
|
homeostasis/metabolism
hypoglycemia
(
J:6337
)
|
• aged mice become hypoglycemic by 9 months of age
|
hyperglycemia
(
J:6337
)
 |
• mutant males, but not females, were transiently hyperglycemic between 2 and 4 months of age
• glucose levels declined thereafter
|
|
• plasma glucagon levels were increased by 3-fold in young mice and 5-fold in aged mice
• pancreatic glucagon content was only doubled compared to controls at 8 months of age
|
|
• at 5 months of age, plasma insulin levels were 30-fold greater in males, and 18-fold greater in females than in controls
• pancreatic insulin levels were 30-fold greater than controls at 8 months of age
|
reproductive system
infertility
(
J:6337
)
|
• mice are sterile
|
digestive/alimentary system
|
• necrosis of the exocrine, but not the endocrine pancreas was noted in aging animals
|
Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| obesity | DOID:9970 |
OMIM:601665 |
J:6337 | |
