Phenotypes Associated with This Genotype

Genotype
MGI:3586835

• Allelic Composition: Htt^tm1Hay/Htt^tm1Hay
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:25941 )

• most die at around E7.5 and E8.5 and all are dead at E9.5

embryonic lethality between implantation and placentation, incomplete penetrance ( J:25941 )

• most die at around E7.5 and E8.5 and all are dead at E9.5

embryo

abnormal gastrulation ( J:25941 )

• gastrulation is disturbed

embryonic growth arrest ( J:25941 )

• E8.5 embryos fail to neurulate, which leads to disorganization of embryos

decreased embryo size ( J:25941 )

• embryos are small and underdeveloped at E7.5

abnormal extraembryonic tissue morphology ( J:25941 )

• extraembryonic membranes are fragmented at E7.5 and a connection between the allanotis and the placenta does not form

growth/size/body

decreased embryo size ( J:25941 )

• embryos are small and underdeveloped at E7.5

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
NOT	Huntington's disease	DOID:12858	OMIM:143100	J:25941