Phenotypes Associated with This Genotype

Genotype
MGI:3586839

• Allelic Composition: Htt^tm1Hay/Htt⁺
• Genetic Background: involves: C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal learning/memory/conditioning ( J:25941 )

• significantly slower to find the hidden platform when it was moved to a new location in the reverse trial of the Morris water maze test, indicating cognitive defects associated with acquiring or using new information in the face of exisiting information

hyperactivity ( J:25941 )

• significantly more active throughout both light- and dark-phases when placed in a novel photocell cage than controls

hyperresponsive ( J:25941 )

• more reactive to handling than controls

nervous system

abnormal globus pallidus morphology ( J:25941 )

• fewer neurons in the globus pallidus, however the caudate/putamen, cerebral cortex, and corpus callosum were normal

abnormal subthalamic nucleus morphology ( J:25941 )

• subthalamic nucleus is decreased in size and volume and contains fewer neurons

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Huntington's disease		DOID:12858	OMIM:143100	J:25941