Phenotypes Associated with This Genotype

Genotype
MGI:3587647

• Allelic Composition: Tg(Cyp19)C2-3Rrte/0
• Genetic Background: involves: BALB/c * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

reproductive system

enlarged testis ( J:60034 )

♂ • infertile males have enlarged testes

male infertility ( J:60034 )

♂ • about 50% of males at 6 - 12 months of age are infertile

neoplasm

increased mammary gland tumor incidence ( J:78693 )

increased fibroadenoma incidence ( J:34063 )

• about 15% of enlarged ducts in virgin females are fibroadenomas

• about 5-10% of hyperplastic ducts in females after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution appear similar to fibroadenomas

increased incidence of tumors by chemical induction ( J:69745 )

• about 25 % of virgin transgenic females exposed to 0.5 ug of DMBA at 56 days of age develop palpable low-grade mammary tumors and all DMBA exposed transgenic females have microscopic evidence of mammary tumor formation or neoplastic progression unlike wild type females

homeostasis/metabolism

increased circulating estradiol level ( J:60034 )

• transgenic males have significantly increased serum estradiol levels compared to wild-type males

increased incidence of tumors by chemical induction ( J:69745 )

• about 25 % of virgin transgenic females exposed to 0.5 ug of DMBA at 56 days of age develop palpable low-grade mammary tumors and all DMBA exposed transgenic females have microscopic evidence of mammary tumor formation or neoplastic progression unlike wild type females

endocrine/exocrine glands

mammary gland duct hyperplasia ( J:34063 )

♀ • in virgin females 40% of ducts are enlarged and 65% of these have hyperplastic lesions while 20% have dysplatic lesions

♀ • after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution about 70-80% of ducts and glands are hyperplastic with numerous terminal ducts seen, in addition 15% show ductal and lobular dysplasia

♀ • ductal hyperplasia is still evident after 5 months of involution

increased mammary gland tumor incidence ( J:78693 )

increased fibroadenoma incidence ( J:34063 )

• about 15% of enlarged ducts in virgin females are fibroadenomas

• about 5-10% of hyperplastic ducts in females after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution appear similar to fibroadenomas

mammary gland hyperplasia ( J:34063 , J:78693 )

♀ • after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution about 70-80% of ducts and glands are hyperplastic with abundant alveolar glands seen, in addition 15% show ductal and lobular dysplasia (J:34063)

♀ • transgenic males display mammary hyperplasia and dysplasia by as early as 3 months of age (J:78693)

enlarged testis ( J:60034 )

♂ • infertile males have enlarged testes

integument

mammary gland duct hyperplasia ( J:34063 )

♀ • in virgin females 40% of ducts are enlarged and 65% of these have hyperplastic lesions while 20% have dysplatic lesions

♀ • after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution about 70-80% of ducts and glands are hyperplastic with numerous terminal ducts seen, in addition 15% show ductal and lobular dysplasia

♀ • ductal hyperplasia is still evident after 5 months of involution

increased mammary gland tumor incidence ( J:78693 )

increased fibroadenoma incidence ( J:34063 )

• about 15% of enlarged ducts in virgin females are fibroadenomas

• about 5-10% of hyperplastic ducts in females after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution appear similar to fibroadenomas

mammary gland hyperplasia ( J:34063 , J:78693 )

♀ • after 1 pregnancy, 3 weeks of lactation and 8 weeks of involution about 70-80% of ducts and glands are hyperplastic with abundant alveolar glands seen, in addition 15% show ductal and lobular dysplasia (J:34063)

♀ • transgenic males display mammary hyperplasia and dysplasia by as early as 3 months of age (J:78693)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
aromatase excess syndrome		DOID:0090122	OMIM:139300	J:78693