Phenotypes Associated with This Genotype

Genotype
MGI:3587757

hm2

• Allelic Composition: Tsc1^tm1Chdl/Tsc1^tm1Chdl
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6JOlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

embryonic lethality during organogenesis, complete penetrance ( J:99796 )

• died between E10.5 and E12.5

• no viable null embryos were observed at E13.5

embryo

decreased embryo size ( J:99796 )

• generally smaller and developmentally retarded

growth/size/body

decreased embryo size ( J:99796 )

• generally smaller and developmentally retarded

nervous system

exencephaly ( J:99796 )

• two out of 12 null embryos displayed exencephaly

cardiovascular system

fetal cardiomyocyte vacuoles ( J:99796 )

• at E12.5, two out of 2 null embryos had abnormal vacuolation of myocardial cells