Phenotypes Associated with This Genotype

Genotype
MGI:3588731

• Allelic Composition: Cln8^mnd/Cln8^mnd
• Genetic Background: involves: B6.KB2 * C3H/HeJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

premature death ( J:1224 , J:56219 )

• Background Sensitivity: death similar to that seen on the inbred B6.KB2 background (J:1224)

nervous system

abnormal nervous system morphology ( J:1224 )

• Background Sensitivity: neurological disease progresses in a similar fashion as on the inbred B6.KB2 background

abnormal motor neuron morphology ( J:56219 )

• Background Sensitivity: exhibit motor neuron disease symptoms at around 6 months of age and do not die prior to 10-12 months of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
neuronal ceroid lipofuscinosis 8		DOID:0110723	OMIM:600143	J:56219