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Phenotypes Associated with This Genotype
Genotype
MGI:3589259
cx4
Allelic
Composition		 Fastm1Osa/Fastm1Osa
Gzmatm1Simn/Gzmatm1Simn
Gzmbtm1Ley/Gzmbtm1Ley
Genetic
Background		 involves: 129P2/OlaHsd * 129S2/SvPas * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Fastm1Osa mutation (7 available); any Fas mutation (82 available)
Gzmatm1Simn mutation (8 available); any Gzma mutation (34 available)
Gzmbtm1Ley mutation (7 available); any Gzmb mutation (29 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
immune system
increased susceptibility to parasitic infection ( J:81397 )
• decreased clearance and survival after infection with Trypanosoma cruzi

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory