Phenotypes Associated with This Genotype

Genotype
MGI:3589405

• Allelic Composition: Edn3^tmgc48/Edn3^tmgc48
• Genetic Background: C57BL/6-19^PWK

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, incomplete penetrance ( J:137432 )

• failure to thrive

• usually die before weaning

behavior/neurological

abnormal social/conspecific interaction behavior ( J:92490 )

• after 3 repeated exposures to scents of the same donor male, females failed to habituate to the presentation of male odors

pigmentation

variable body spotting ( J:137432 )

• heritable white spotting phenotype

• severe white spotting over most of the body

• pigmentation remains only around pinnae, eyes, tail

integument

variable body spotting ( J:137432 )

• heritable white spotting phenotype

• severe white spotting over most of the body

• pigmentation remains only around pinnae, eyes, tail

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Waardenburg syndrome type 4B		DOID:0110954	OMIM:613265	J:137432