Analysis Tools
mortality/aging
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• death occurs as early as P18 and most die between 19 and 22 days, although a few survive to 30 days
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growth/size/body
small ears
(
J:10398
)
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• from 14-18 days there is a marked retardation of growth although animals are normal in size before then
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• about four times the normal weight
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vision/eye
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• closed eyelids in almost all 14 day or older mice due to conjunctivitis
• eyelid aperature is small
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hearing/vestibular/ear
small ears
(
J:10398
)
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reproductive system
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• reddening and swelling of the genital papilla at P12-14
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cryptorchism
(
J:10398
)
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• testes are abdominal or inguinal
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small gonad
(
J:10398
)
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• reproductive structures are extremely underdeveloped
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immune system
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• about four times the normal weight
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• hyperplasia of the red pulp
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• architecture of the spleen is disrupted, with white and red pulp intermingling
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• hyperplasia of the white pulp
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hematopoietic system
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• persistence of hematopoiesis in the liver
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• depletion of the number of megakaryocytes with age in the bone marrow
• megakaryocytes are reduced at 13 days of age, more reduced at 17 days of age, and almost absent from the spleen at 20 days of age
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• low at birth and decrease as disease progresses
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• older animals exhibit hypochromic red blood cells
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• low at birth and decrease as disease progresses
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• increased reticulocyte count
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• about four times the normal weight
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• hyperplasia of the red pulp
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• architecture of the spleen is disrupted, with white and red pulp intermingling
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• hyperplasia of the white pulp
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liver/biliary system
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• liver is dotted with yellow foci in some animals, suggesting infection
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pale liver
(
J:10398
)
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renal/urinary system
pale kidney
(
J:10398
)
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behavior/neurological
cardiovascular system
digestive/alimentary system
respiratory system
endocrine/exocrine glands
cryptorchism
(
J:10398
)
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• testes are abdominal or inguinal
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craniofacial
small ears
(
J:10398
)
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integument
scaly skin
(
J:10398
)
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• first visible on the underside of the tail and later on other body parts
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tight skin
(
J:10398
)
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Mouse Models of Human Disease |
DO ID | OMIM ID(s) | Ref(s) | |
| Wiskott-Aldrich syndrome | DOID:9169 |
OMIM:301000 |
J:10398 | |
