Phenotypes for Cd4 Foxp3 Otc MGI:3590077 MGI Mouse

premature death ( J:20865 )

• signs of scurfy disease are delayed and are first seen at 4 weeks of age, with mutants dying at about 6 weeks of age

• increase in the percentage of CD4-CD8+CD44+ and CD4-CD8+CD45RB^dull T cells compared to homozygous CD4 mice at 15 days of age

• decrease in the percentage of CD4-CD8+ T cells in aged mutants compared with aged homozygous CD4 mice

increased IgG level ( J:20865 )

• increased IgG in 35 day or older mutants, but not in 15 day old mutants

increased IgM level ( J:20865 )

• increased IgM in 35 day or older mutants, but not in 15 day old mutants

• lymphoid organs in 15 day old mutants have typical scurfy lesions in T cell areas, but quiescent B cell areas

enlarged lymph nodes ( J:20865 )

• lymph nodes are normal size at day 15 but are enlarged by day 35

abnormal cytokine secretion ( J:20865 )

increased interleukin-4 secretion ( J:20865 )

• increased IL-4 production in response to Con A stimulation in aged (P45), but not young (P16) mice, compared to homozygous Cd4 mutant mice

increased interleukin-6 secretion ( J:20865 )

• increased IL-6 production in response to Con A stimulation in aged (P45), but not young (P16) mice, compared to homozygous Cd4 mutant mice

• increased TNF-alpha production in response to Con A stimulation in aged (P45), but not young (P16) mice, compared to homozygous Cd4 mutant mice