Phenotypes Associated with This Genotype

Genotype
MGI:3590685

• Allelic Composition: Gck^tm1.2Mgn/Gck^tm1.2Mgn
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

postnatal lethality, complete penetrance ( J:51826 )

• die within 4 days of birth from severe diabetes

homeostasis/metabolism

hyperglycemia ( J:51826 )

• plasma glucose concentration of 566 mg/dl compared to 73 mg/dl in wild-type, at 2 days of age

decreased circulating insulin level ( J:51826 )

• reduced by approximately 70%

increased circulating free fatty acids level ( J:51826 )

• about 1.8-fold increase

decreased liver glycogen level ( J:51826 )

• diminished hepatic glycogen

liver/biliary system

decreased liver glycogen level ( J:51826 )

• diminished hepatic glycogen

hepatic steatosis ( J:51826 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:51826