Phenotypes Associated with This Genotype

Genotype
MGI:3590686

• Allelic Composition: Gck^tm1.2Mgn/Gck⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:51826 )

• insulin secretion in response to the hyperglycemic clamp is decreased by 60%

hyperglycemia ( J:51826 )

• plasma glucose concentration increases over time (117 mg/dl vs. 73 mg/dl in wild-type at 2 days and 304 mg/dl vs. 175 mg/dl in wild-type at 6-10 weeks of age)

impaired glucose tolerance ( J:51826 )

• 70% reduction in glucose infusion rate in hyperglycemic clamp studies

decreased liver glycogen level ( J:51826 )

• intermediate levels of hepatic glycogen under normal conditions

• hepatic glycogen synthesis is decreased by more than 90% in response to the hyperglycemic clamp

liver/biliary system

decreased liver glycogen level ( J:51826 )

• intermediate levels of hepatic glycogen under normal conditions

• hepatic glycogen synthesis is decreased by more than 90% in response to the hyperglycemic clamp

hepatic steatosis ( J:51826 )

• intermediate amount of steatosis

endocrine/exocrine glands

decreased insulin secretion ( J:51826 )

• insulin secretion in response to the hyperglycemic clamp is decreased by 60%

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:51826