Phenotypes Associated with This Genotype

Genotype
MGI:3603012

• Allelic Composition: Gck^tm1.1Mgn/Gck⁺; Tg(Ins2-cre)25Mgn/0
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:51826 )

• 70% decrease in insulin secretion during hyperglycemic clamp studies

hyperglycemia ( J:51826 )

• blood glucose concentration is increased by about 50% compared to heterozygous Gck^tm1.1Mgn mice

• under fasting conditions, have a 25% increase in blood glucose concentration, without differences in basal insulin concentration

impaired glucose tolerance ( J:51826 )

• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced by about 60 and 70%, respectively

decreased glycogen level ( J:51826 )

• net glycogen synthesis in liver is reduced by about 50% during hyperglycemic clamp studies

endocrine/exocrine glands

decreased insulin secretion ( J:51826 )

• 70% decrease in insulin secretion during hyperglycemic clamp studies

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:51826