Phenotypes Associated with This Genotype

Genotype
MGI:3603013

• Allelic Composition: Gck^tm1.1Mgn/Gck^tm1.1Mgn; Speer6-ps1^{Tg(Alb-cre)21Mgn}/Speer6-ps1⁺
• Genetic Background: involves: 129S6/SvEvTac * C57BL/6 * DBA/2

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

abnormal glucose homeostasis ( J:51826 )

decreased insulin secretion ( J:51826 )

• secrete 70% less insulin in response to glucose stimulus

increased circulating glucose level ( J:51826 )

• 10% increase in fed blood glucose concentration

increased circulating insulin level ( J:51826 )

• post-absorptive (fed) plasma insulin concentrations twice that of controls

impaired glucose tolerance ( J:51826 )

• glucose turnover and glucose infusion rates during hyperglycemic clamp are reduced

decreased glycogen level ( J:51826 )

• net hepatic glycogen synthesis is reduced by about 90% during hyperglycemic clamp studies

insulin resistance ( J:51826 )

• mild insulin resistance

endocrine/exocrine glands

decreased insulin secretion ( J:51826 )

• secrete 70% less insulin in response to glucose stimulus

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 2		DOID:0111100	OMIM:125851	J:51826