Phenotypes Associated with This Genotype

Genotype
MGI:3603406

• Allelic Composition: Tg(Ins2-TCF1*P291)2Kya/0
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

homeostasis/metabolism

decreased insulin secretion ( J:73760 )

• decreased glucose-stimulated insulin secretion

hyperglycemia ( J:73760 )

• nonfasting blood glucose levels at 4 weeks are higher, especially in males

endocrine/exocrine glands

abnormal pancreatic islet morphology ( J:73760 )

• islets are smaller in size, contain fewer insulin-positive cells, and are irregularly shaped

decreased pancreatic beta cell number ( J:73760 )

• decreased by 50% and 58% at 2 and 4 weeks of age, respectively

small pancreatic islets ( J:73760 )

disorganized pancreatic islets ( J:73760 )

• beta-cells intermingle with non-beta-cells within the islet core and compacted beta-cell-to-beta-cell contact is abolished

abnormal pancreatic beta cell physiology ( J:73760 )

• reduced changes in intracellular calcium in islets in response to glucose

• reduced pancreatic insulin content

• reduced beta-cell proliferation in islets

decreased pancreatic beta cell proliferation ( J:73760 )

• reduced beta-cell proliferation in islets

decreased insulin secretion ( J:73760 )

• decreased glucose-stimulated insulin secretion

cellular

decreased pancreatic beta cell proliferation ( J:73760 )

• reduced beta-cell proliferation in islets

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
maturity-onset diabetes of the young type 3		DOID:0111102	OMIM:600496	J:73760