Phenotypes Associated with This Genotype

Genotype
MGI:3604113

• Allelic Composition: Csf2rb^tm1Mur/Csf2rb^tm1Mur
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased eosinophil cell number ( J:35829 )

• the number of eosinophils in the peripheral blood is reduced

abnormal eosinophil physiology ( J:35829 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, response to bacterial infection and hematopoietic cell recovery after treatment with a cytotoxic agent are normal

lung inflammation ( J:35829 )

• peribronchovascular lymphocytic infiltration

respiratory system

lung inflammation ( J:35829 )

• peribronchovascular lymphocytic infiltration

abnormal pulmonary alveolus morphology ( J:35829 )

• a focal but scattered intraalveolar proteinacious substance is seen associated with expanded foamy pulmonary alveolar macrophages

hematopoietic system

abnormal myeloblast morphology/development ( J:35829 )

• no colonies are formed in vitro in the presence of granulocyte-macrophage colony-stimulating factor or IL-5

decreased eosinophil cell number ( J:35829 )

• the number of eosinophils in the peripheral blood is reduced

abnormal eosinophil physiology ( J:35829 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, response to bacterial infection and hematopoietic cell recovery after treatment with a cytotoxic agent are normal

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary alveolar proteinosis		DOID:12120	OMIM:265120 OMIM:300770 OMIM:610913 OMIM:610921 OMIM:614370	J:35829