Phenotypes Associated with This Genotype

Genotype
MGI:3604114

• Allelic Composition: Csf2rb^tm1Mur/Csf2rb^tm1Mur
• Genetic Background: involves: 129P2/OlaHsd

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

immune system

decreased eosinophil cell number ( J:24122 )

• the number of eosinophils in the peripheral blood is reduced; however, the number of other peripheral blood cells, bone marrow, spleen, and peritoneal cells are all normal

abnormal eosinophil physiology ( J:24122 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, serum IgE levels are increased after infection

lung inflammation ( J:24122 )

• peribronchovascular lymphocytic infiltration

increased susceptibility to infection ( J:24122 )

• no eosinophilia or pulmonary granulomatous lesions are seen 14 days after infection with the nematode, N brasiliensis; however severe lung edema and diffuse infiltration of mononuclear cells and neutrophils are seen and 21 days after infection lung inflammation persists

respiratory system

lung inflammation ( J:24122 )

• peribronchovascular lymphocytic infiltration

abnormal pulmonary alveolus morphology ( J:24122 )

• a focal but scattered intraalveolar proteinacious substance is seen associated with expanded foamy pulmonary alveolar macrophages

hematopoietic system

abnormal myeloblast morphology/development ( J:24122 )

• no colonies are formed in vitro in the presence of granulocyte-macrophage colony-stimulating factor or IL-5

decreased eosinophil cell number ( J:24122 )

• the number of eosinophils in the peripheral blood is reduced; however, the number of other peripheral blood cells, bone marrow, spleen, and peritoneal cells are all normal

abnormal eosinophil physiology ( J:24122 )

• no eosinophilia is seen in response to infection with the nematode, N brasiliensis; however, serum IgE levels are increased after infection

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
pulmonary alveolar proteinosis		DOID:12120	OMIM:265120 OMIM:300770 OMIM:610913 OMIM:610921 OMIM:614370	J:24122