Phenotypes Associated with This Genotype

Genotype
MGI:3604219

• Allelic Composition: Fmr1^tm1.1Cidz/Fmr1^tm1.1Cidz; Tg(Pcp2-cre)2Mpin/0
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

abnormal eye blink conditioning behavior ( J:101021 )

♀ • the percentage, amplitude, and velocity of conditioned responses were reduced in the 3rd and 4th training sessions; however the startle response was normal

nervous system

abnormal Purkinje cell morphology ( J:101021 )

♀ • the length of Purkinje cell spine heads and necks is increased

abnormal long-term depression ( J:101021 )

♀ • induction of long term depression in Purkinje cells is significantly enhanced when stimulating parallel fibers

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
fragile X syndrome		DOID:14261	OMIM:300624	J:101021