Phenotypes Associated with This Genotype

Genotype
MGI:3604390

• Allelic Composition: Park7^tm1Xz/Park7^tm1Xz
• Genetic Background: involves: 129P2/OlaHsd * C57BL/6J

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

impaired limb coordination ( J:99905 )

• at 5 and 11 months of age, homozygotes show an impaired ability to remove a strip of adhesive tape from their forehead; however no difference is seen in performance in the rotarod test

decreased vertical activity ( J:99905 )

• at 11 months of age, locomotor and rearing activities are reduced in the open field test

decreased locomotor activity ( J:99905 )

• at 11 months of age, locomotor and rearing activities are reduced in the open field test

homeostasis/metabolism

increased dopamine level ( J:99905 )

• at 4 months of age stimulated dopamine release is increased and dopamine uptake is faster in the dorsal caudate-putamen; however, no difference in dopamine release or uptakes is seen in the ventral caudate putamen

• at 6 and 11 months of age dopamine levels are increased in the caudate-putamen; however the number of dopaminergic neurons is normal and no obvious signs of neuropathology are seen

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Parkinson's disease 7		DOID:0060370	OMIM:606324	J:99905