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Phenotypes Associated with This Genotype
Genotype
MGI:3604406
cx27
Allelic
Composition		 Il11ra1tm1Wehi/Il11ra1tm1Wehi
Il6tm1Kopf/Il6tm1Kopf
Genetic
Background		 involves: 129/Sv * C57BL/6
Find Mice Using the International Mouse Strain Resource (IMSR)
Mouse lines carrying:
Il11ra1tm1Wehi mutation (1 available); any Il11ra1 mutation (37 available)
Il6tm1Kopf mutation (9 available); any Il6 mutation (38 available)
♀ phenotype observed in females
♂ phenotype observed in males
N normal phenotype
digestive/alimentary system
increased susceptibility to induced colitis ( J:79073 )
• adult double homozygotes do NOT develop spontaneous gastric hyperplasia or gastric adenomas
• however, double homozygotes exhibit enhanced colitis in response to DSS-mediated intestinal injury, as shown by increased inflammation, crypt damage, severe weight loss, and increased morbidity relative to wild-type or Il11ra1tm1Wehi mice

immune system
increased susceptibility to induced colitis ( J:79073 )
• adult double homozygotes do NOT develop spontaneous gastric hyperplasia or gastric adenomas
• however, double homozygotes exhibit enhanced colitis in response to DSS-mediated intestinal injury, as shown by increased inflammation, crypt damage, severe weight loss, and increased morbidity relative to wild-type or Il11ra1tm1Wehi mice

Contributing Projects:
Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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Send questions and comments to User Support. 		last database update
12/10/2024
MGI 6.24 		The Jackson Laboratory
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