Phenotypes Associated with This Genotype

Genotype
MGI:3604733

cx5

• Allelic Composition: Flg^ft/Flg^ft; Tmem79^ma/Tmem79^ma
• Genetic Background: involves: C57BL/6J * CBA/CaGr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

integument

integument phenotype ( J:30359 )

N • mice were examined at 5 weeks of age when the effects of the flaky-skin mutation on skin condition are not yet seen

abnormal coat/ hair morphology ( J:30359 )

abnormal coat appearance ( J:30359 )

• clumped hair and bald spots develop in mutant mice by 4 weeks of age

• the hair of older non-agouti black mice may appear brown although a pigment defect is not reported

alopecia ( J:30359 )

• bald patches occur in areas that are rubbed, breaking hair shafts

matted coat ( J:30359 )

• clumped hair can be seen in mutant mice by 4 weeks of age

• saliva introduced during grooming causes the hair to mat

• the matted appearance is easily seen when the fur is stroked opposite the normal direction of the coat

abnormal hair shaft morphology ( J:30359 )

• hair shaft above matrix does not develop normally in some mutant mice

• hairs tend to break and split

abnormal hair follicle matrix region morphology ( J:30359 )

• found where hair shafts become structurallly abnormal