Phenotypes Associated with This Genotype

Genotype
MGI:3604778

hm3

• Allelic Composition: Tmem79^ma/Tmem79^ma
• Genetic Background: involves: C57BL/Gr * CBA/CaGr

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

pigmentation

darkened coat color ( J:12996 )

• the matted hair exposes the black basal part of agouti hair, making the coat appear russet rather than black however there is no affect on pigment other than that found in the normal ageing process in C57 black mice

• the timing of changes in the coat color indicates early ageing in mutant mice

integument

abnormal coat appearance ( J:12996 )

• areas of small clumps contribute to a rough appearance

darkened coat color ( J:12996 )

• the matted hair exposes the black basal part of agouti hair, making the coat appear russet rather than black however there is no affect on pigment other than that found in the normal ageing process in C57 black mice

• the timing of changes in the coat color indicates early ageing in mutant mice

abnormal hair growth ( J:12996 )

• hairs are brittle and tend to split longitudinally

alopecia ( J:12996 )

• belly and head are rarely affected

• there is variable loss over the back and flanks due to rubbing on environmental surfaces

• baldness results from breakage above the skin rather than from patchy hair loss or failure of hairto regrow after molting

matted coat ( J:12996 )

• largest clumps involve dorsal long hair where least density

• areas of small clumps contribute to a rough appearance

• clumping is an outcome of grooming, saliva adhering distal hair shafts