Phenotypes for Lrp5 MGI:3606583 MGI Mouse

cardiovascular system

decreased angiogenesis ( J:328283 )

• delayed superficial blood vessel growth in retina

• reduced vascular density in retina

hemorrhage ( J:328283 )

• extensive blood leakage in retina

vision/eye

abnormal retina development ( J:328283 )

• delayed superficial blood vessel growth

• reduced vascular density

• extensive blood leakage

abnormal retina layer morphology ( J:101679 )

• changes related to degeneration are more prominent in the outer layers of the retina (photoreceptor layers) and least pronounced in the inner layers

retina ganglion cell degeneration ( J:101679 )

• loss of ganglion cell nuclei, especially large ganglion cells, is seen in some degenerating retinas

retina photoreceptor degeneration ( J:101679 )

• degeneration of the photoreceptors is seen in some degenerating retinas

abnormal retina pigment epithelium morphology ( J:101679 )

• thinning and vacuolation of the pigment epithelium layer are seen in some degenerating retinas

disorganized retina inner nuclear layer ( J:101679 )

• disorganization of the inner nuclear layer is seen in some degenerating retinas

thin retina inner plexiform layer ( J:101679 )

• thinning of the inner plexiform layer is seen in some degenerating retinas

abnormal retina nerve fiber layer morphology ( J:101679 )

• gliosis of the retinal nerve fiber layer is seen in some degenerating retinas

abnormal retina outer nuclear layer morphology ( J:101679 )

• thinning, disorganization, and pyknosis of the outer nuclear layer are seen in some degenerating retinas

thin retina outer nuclear layer ( J:101679 )

disorganized retina outer nuclear layer ( J:101679 )

abnormal retina outer plexiform layer morphology ( J:101679 )

• thinning and disorganization of the outer plexiform layer, sometimes with juxtaposition of the photoreceptor nuclei and the bipolar cell or inner nuclear layer, are seen in some degenerating retinas

disorganized retina outer plexiform layer ( J:101679 )

thin retina outer plexiform layer ( J:101679 )

increased susceptibility to age-related retinal degeneration ( J:101679 )

• at 7 weeks of age mild to severe retinal degeneration is seen and at 10 months of age all homozygotes display moderate to severe retinal degeneration

• severity of degeneration usually differs between the two eyes of affected homozygotes

retina fold ( J:101679 )

• retinal folds are seen in some degenerating retinas

behavior/neurological

increased thigmotaxis ( J:101679 )

• homozygotes spend significantly less time in the central region in an open field test

decreased locomotor activity ( J:101679 )

• homozygotes travel less total distance in an open field test

nervous system

gliosis ( J:101679 )