Phenotypes Associated with This Genotype

Genotype
MGI:3606787

• Allelic Composition: Tg(Lim2*G15V)1Rlc/Tg(Lim2*G15V)1Rlc
• Genetic Background: involves: C57BL/6 * SJL

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

vision/eye

abnormal lens epithelium morphology ( J:100078 )

• in histologic sections of eyes from E15 homozygous transgenic embryos, the lens epithelium appears thickened

disorganized secondary lens fibers ( J:100078 )

• histologic examination of the lenses of homozygous transgenic mice at embryonic days E15 and E19 and at postnatal day P18 reveals gross disorganization of the secondary fibers

total cataract ( J:100078 )

• homozygous transgenic mice have severe, total bilateral cataracts

disorganized lens bow ( J:100078 )

• in histologic sections of eyes from E15 homozygous embryos, disorganization of the lens bow region is apparent; sections of E19 transgenic eyes show more rapid progression of the abnormality in homozygous than in heterozygous animals

small lens ( J:100078 )

• upon histologic examination of the eyes, the lenses of homozygous transgenic mice are obviously smaller than those of heterozygous transgenic or wildtype mice, approximately the size of the nuclei of the latter animals' lenses; this difference is apparent by embryonic day E15 and remains obvious

microphthalmia ( J:100078 )

• homozygous transgenic mice present with severe, grossly obvious microphthalmia; their eyes weigh on average 63% less than those of wildtype littermates at 20 days of age

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
cataract 19 multiple types		DOID:0110263	OMIM:615277	J:100078