Phenotypes Associated with This Genotype

Genotype
MGI:3607781

• Allelic Composition: Ndn^tm1Ky/Ndn⁺
• Genetic Background: involves: C57BL/6 * CBA * ICR/Slc

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

behavior/neurological

increased thermal nociceptive threshold ( J:100024 )

• at P14 and P29 in mice with a paternally inherited allele, latencies in the hotplate and tail-flick test are about 2-fold greater than those of wild-type mice; however, no postnatal lethality is seen when this allele is paternally inherited on an ICR background

nervous system

abnormal dorsal root ganglion morphology ( J:100024 )

• when this allele is paternally inherited a 1.6- to 1.8-fold increase in apoptosis is seen in the cervical dorsal root ganglia at E12.5

• the density of nociceptive neurons (substance P-containing) is reduced to 59% that in wild-type mice at P0

• at P0 the total neuron number is reduced to 88% that in wild-type mice

cellular

maternal imprinting ( J:100024 )

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Prader-Willi syndrome		DOID:11983	OMIM:176270	J:100024