Phenotypes Associated with This Genotype

Genotype
MGI:3611210

• Allelic Composition: App^tm1.1Cep/App^tm1.1Cep; Psen1^tm1Dgf/Psen1^tm1Dgf
• Genetic Background: involves: 129S1/Sv * 129X1/SvJ * CD-1

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

nervous system

amyloid beta deposits ( J:66147 , J:102425 )

• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)

• amyloid-beta deposition beginning at 6 months of age (J:102425)

• deposition increased linearly over time (J:102425)

homeostasis/metabolism

amyloid beta deposits ( J:66147 , J:102425 )

• mutants exhibit enhanced amyloidogenic APP processing in cortical neurons and accelerated onset of amyloid deposition (J:66147)

• amyloid-beta deposition beginning at 6 months of age (J:102425)

• deposition increased linearly over time (J:102425)

Mouse Models of Human Disease		DO ID	OMIM ID(s)	Ref(s)
Alzheimer's disease		DOID:10652		J:102425