Phenotypes Associated with This Genotype

Genotype
MGI:3611560

ht2

• Allelic Composition: Adm^tm1Tfjt/Adm⁺
• Genetic Background: involves: C57BL/6 * CBA

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

cardiovascular system

abnormal coronary artery morphology ( J:102946 )

• in severe cases fibrinoid necrosis is seen in the perivascular area of the coronary artery in heterozygous mice given angiotensin II and fed a high salt diet

blood vessel inflammation ( J:102946 )

• inflammation of the perivascular area of the coronary artery is more severe in heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice

cellular

oxidative stress ( J:102946 )

• elevated urinary excretion of 8-hydroxydeoxyguanosine and isoprostane, elevated expression of Ncf2 and Cybb, and increased 3-nitrotyrosine staining all indicate elevated oxidative stress in the hearts of heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice

immune system

blood vessel inflammation ( J:102946 )

• inflammation of the perivascular area of the coronary artery is more severe in heterozygous mice given angiotensin II and fed a high salt diet compared to similarly treated wild-type mice