Phenotypes Associated with This Genotype

Genotype
MGI:3612387

hm2

• Allelic Composition: Hoxa5^tm1Rob/Hoxa5^tm1Rob
• Genetic Background: B6.129S(Cg)-Hoxa5^tm1Rob

• ♀: phenotype observed in females
• ♂: phenotype observed in males
• N: normal phenotype

mortality/aging

neonatal lethality, incomplete penetrance ( J:45341 )

• 85% of mice that die, die within 24 hours of birth

postnatal lethality, incomplete penetrance ( J:45341 )

• Background Sensitivity: few survivors (3%) at weaning, unlike mice on an inbred 129 background where about 16% survive to weaning

skeleton

abnormal cricoid cartilage morphology ( J:45341 )

• always larger than thyroid cartilage

decreased tracheal cartilage ring number ( J:45341 )

respiratory system

abnormal cricoid cartilage morphology ( J:45341 )

• always larger than thyroid cartilage

impaired branching involved in bronchus morphogenesis ( J:45341 )

• reduced branching of the bronchial tree

atelectasis ( J:45341 )

• high proportion of collapsed lungs at autopsy

thick pulmonary interalveolar septum ( J:45341 )

• thickened alveolar walls and areas of poorly inflated alveoli

abnormal trachea morphology ( J:45341 )

• disorganized tracheal epithelium and a thickened lamina propria

decreased tracheal cartilage ring number ( J:45341 )

trachea occlusion ( J:45341 )

• tracheal occlusion frequent

decreased surfactant secretion ( J:45341 )

• reduced levels of pulmonary surfactant proteins

vision/eye

delayed eyelid opening ( J:45341 )

• in mice surviving to adulthood

growth/size/body

meteorism ( J:45341 )

• air in stomach and intestines at death

postnatal growth retardation ( J:45341 )

• in mice surviving to adulthood

digestive/alimentary system

meteorism ( J:45341 )

• air in stomach and intestines at death